Smoke versus Vapor

The Tobacco Industry vs the Electronic Cigarette


Esmoke Safety Reports

ON BEHALF OF NJOY, CEO Jack Leadbeater
July 23, 2009
NJOY RESPONSE TO FDA CONFERENCE CALL

NJOY products have been on the market since at least April 2007 with no reports of significant adverse health consequences. We do not market our products to children, and indeed take affirmative steps to ensure that our products are not sold to minors by requiring retailers to agree to where the product is placed and request verification of appropriate age as it pertains to eachstate law.

You can read the entire Statement  here.



Green Smoke Safety Report

I have also included an available report from another electronic cigarette company that also shows additives and ingredients which are well within the parameters of safety as per the requirements of the FDA for other nicotine products available at this time.

Green Smoke Safety Report



Gamucci Safety Report

Report Number: E98D

Analysis of Components from Gamucci Electronic Cigarette

March 3rd 2009

On balance, the nicotine solution appears to offer a much safer alternative to the traditional cigarette, since it does not appear to contain the toxic cocktail of toxic compounds found in traditional tobacco smoke, where 600+ chemicals have been identified, of which many are carcinogenic.

The primary aerosol forming solvent (propylene glycol) used in the preparation of the nicotine solution is listed as a suspected respiratory toxicant. It has been suggested that the aerosol forming solvent from the suspected respiratory toxicant "Propylene Glycol", be changed to an even safer solvent such as glycerol in the event that the solvent becomes added to the list of respiratony toxicants in the foreseeable future.

LPD Lab Services Test Report




E-cigarette Safety: Ruyan e-cigarette Benchtop Tests




The mist of the e-cigarette has been rigorously tested. Of over 50 priority-listed cigarette smoke toxicants tested, none was detectable in the mist of the Ruyan e-cigarette, except for a trace of mercury close to the limit of detection. Some toxicants remain to be tested before the results are submitted for publication.  On the basis of findings to date, inhaling mist from the e-cigarette is rated several orders of magnitude (100 to 1000 times) less dangerous than smoking tobacco cigarettes. The nicotine dose per puff is comparable to that of a medicinal nicotine inhaler. E-cigarette nicotine is apparently not absorbed from the lung, but from the upper airways.

You can find the full Report  here





Safety Report on the Ruyan e-cigarette Cartridge and
Inhaled Aerosol


Murray Laugesen
Health New Zealand Ltd
Christchurch, New Zealand.
www.healthnz.co.nz

30 October 2008

Ruyan e-cigarette Cartridge Report @ Health New Zealand Ltd. 30 October 2008

Foreword

This safety report includes Health New Zealands findings to date. Ruyan has allowed flexibility in the nature of investigations carried out. The tests reported are backed up by signed reports from the contracted laboratories. No completed test results have been withheld.

This version of the report includes results of further tests on mist and cartridges reported from the laboratories since the last version on 21 October 2008. The overall conclusions of the report are unchanged.

Source of funding and disclaimer

The Ruyan e-cigarettes and the funds for testing them were supplied under a contract by Ruyan (Holdings) Ltd Hong Kong, but the findings are those of the author. Neither the author nor Health New Zealand Ltd holds stock in Ruyan (Holdings) Co. Ltd.

(Dr) Murray Laugesen

Lyttelton, Christchurch, 8082, New Zealand.


30 October, 2008

Summary

Aim. This report aims to assist regulators in initial assessment of the safety of the Ruyan e-cigarette and its cartridges, and the possible risks and benefits from permitting its use Method. Health New Zealand Ltd contracted with seven leading government, university and commercial laboratories in New Zealand and Canada to independently perform various tests on the Ruyan cigarette nicotine refill cartridge.

Findings. Ruyan e-cigarette is designed to be a safe alternative to smoking. The various test results confirm this is the case. It is very safe relative to cigarette, and also safe in absolute terms on all measurements we have applied. Using micro-electronics it vaporizes, separately for each puff, very small quantities of nicotine dissolved in propylene glycol, two small well-known molecules with excellent safety profiles, into a fine aerosol. Each puff contains one third to one half the nicotine in a tobacco cigarette puff. The cartridge liquid is tobacco-free and no combustion occurs.


Financial disclosure. This report is funded by Ruyan.

Disclaimer. Apart from research Health New Zealand derives no financial benefit from Ruyan.

Ruyan e-cigarette Cartridge Report @ Health New Zealand Ltd. 30 October 2008

Limitation. Unless the contrary is stated, findings refer specifically to Ruyan e-cigarettes only.


Safety of the Ruyan cartridge liquid and inhaled aerosol

1. Propylene Glycol

Summary: Propylene glycol (PG) is virtually non-toxic.

According to the manufacturer, propylene glycol makes up 89-90% of the liquid in the nicotine cartridge that generates the mist and vapor in the e-cigarette


You can read the full report here.

Competency. The author has authored or co-authored over 30 research papers and reports in national and international scientific medical journals since 1995, on smoking, and latterly on testing of cigarettes and cigarette substitutes.






HOW SAFE IS
AN E-CIGARETTE?
THE RESULTS OF INDEPENDENT
CHEMICAL AND
MICROBIOLOGICAL ANALYSIS


Murray Laugesen*
Simon Thornley#
Hayden McRobbie**
Chris Bullen**

Conflict of Interest and Disclosure statement
This work is part of a research contract between the Health New Zealand Ltd and
Ruyan Group Holdings, Beijing.
No financial benefit accrues and no Ruyan stock is held by Health New Zealand Ltd or the author

You can read the full report here.   


* Health New Zealand Ltd, Christchurch NZ.     www.healthnz.co.nz

# Public Health Medicine Registrar, Auckland District Health Board, NZ
**Clinical Trials Research Unit, University of Auckland, NZ.    www.ctru.auckland.ac.nz/




There are between 7 and 11 manufactures of the Electronic cigarettes, cigars and pipes in the Southern China, where most of those devices come from. It is a very open research and development set-up that rules and most of the products come from the same source and therefore the same technology. There is the voice technology technique that makes the atomizers work based on voice, noise, blows, puffs or loud tones and there are the Air flow technology that only operates on drags on the products. 3 manufacturers are very open for their innovation and are prepared to share their findings and development with us.

AcceptableChoice have visited 9 factories and evaluated those and their products. From this evaluation set-up a number of research materials, documents, analysis and documents have been available and is the basis for some of the findings in this report.

In order to debate the products properly, you need to separate the products in the electronic device and the filters with the substance.



Main Ingredient

Manufacturers content

Eurofins Findings

FEMA/CAS No/CoE

1

TOBACCO ESSENCIAL OILVIRGINIA  (flavour substance)

<5%


Natural from tobacco

2

TOBACCO ABSOLUTEVIRGINIA (flavour substance)

<5%


Natural from tobacco

3

TOBACCO ABSOLUTEBURLEY (flavour substance)

<5%


Natural from tobacco

4

ORIENT TOBACCO ABSOLUTE (flavour substance)

<5%


Natural from tobacco

5

235-TRIMETHYLPYRAZINE

<1%


3244/14667-55-1/CoE735

6

23-DIMETHYLPYRAZINE

<1%


3271/CoE11323

7

25-DIMETHYLPYRAZINE

<1%


3272/CoE2210

8

2-ETHYLPYRAZINE

<1%


3281/Coe2213

9

2-ACETYLPYRAZINE

<1%


3126 /22047-25-2/CoE2286

10

266-TRIMETHYLCYCLOHEX-2-BUTENE-4-ONE



3420

11

BETA-IONONE

<5%


2595/FDA172.515

12

LINALOOL

<2%


2635/000126-90-9

13

MENTHOL

<2%

910

2665/000089-78-1

14

METHYL BUTYRIC ACID (2-)

<2%


2695/000116-53-0

15

Rose oil, bulgarian, true otto

<2%


2989/008007-01-0

16

Vanilla extract

<5%


008024-06-4

17

Octalactone (gamma-)

<1%


104-50-7

18

Undecalactone (gamma-)

<1%


104-67-6

19

PURE WATER

<20%


7732-18-5

20

PROPYLENE GLYCOL

>50%

290.000

2940/57-55-6

21

GLYCEROL

>10%

28

2525/000056-81-5


Below are a few of the different electronic cigarette liquid solution compositions available:


SubstanceRecipe 1Recipe 2Recipe 3Recipe 4
Propylene glycol



85%80%90%80%
Nicotine



6%

4%2%0.1%
Glycerol



2%5%-5%
Tobacco essence



-

4%4.5%1%
Essence



2%

-
1%1%
Organic acid



1%

-
-2%
Anti-oxidation agent



1%

-

--
Butyl valerate



-

1%
-
-
Isopentyl hexonate



-
1%
-
-
Lauryl laurate


-
0.6%-
-
Benzyl benzoate



-
0.4%-
-
Methyl octynicate



-
0-5%-
-
Ethyl heptylate



-
0.2%-
-
Hexyl hexanoate



-
0.3%-
-
Geranyl butyrate



-
2%-
-
Menthol



-
0.5%-
-
Citric acid



-
0.5%2.5%-
Water



-
-
-
2.9%
Alcohol



-
-
-
8%